Start Date

2019

Description

Giardia are parasitic single-cell eukaryotes. While mostly known for causing giardiasis in humans, we are studying Giardia because they are evolutionarily close to the last common eukaryotic ancestor, so understanding their genome gives us information about all eukaryotic evolution. This project is looking at the specific proteins that are in the nuclear pore complexes (NPCs) of Giardia. These pores are what allow transport of biomolecules between the nucleus and cytoplasm. Though the architecture of NPCs is similar between eukaryotes, the specific gene sequences are highly divergent.

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Jan 1st, 12:00 AM

Giardia lamblia nuclear pore complex proteins

Giardia are parasitic single-cell eukaryotes. While mostly known for causing giardiasis in humans, we are studying Giardia because they are evolutionarily close to the last common eukaryotic ancestor, so understanding their genome gives us information about all eukaryotic evolution. This project is looking at the specific proteins that are in the nuclear pore complexes (NPCs) of Giardia. These pores are what allow transport of biomolecules between the nucleus and cytoplasm. Though the architecture of NPCs is similar between eukaryotes, the specific gene sequences are highly divergent.