Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Authors

Kristina M. Adams Waldorf, University of Washington
Jennifer E. Stencel-Baerenwald, University of Washington
Raj P. Kapur, University of Washington
Colin Studholme, University of Washington
Erica Boldenow, Calvin University

Document Type

Article

Publication Title

Nature Medicine

Abstract

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

First Page

1256

Last Page

1259

DOI

10.1038/nm.4193

Publication Date

11-1-2016

Recommended Citation

Adams Waldorf, Kristina M.; Stencel-Baerenwald, Jennifer E.; Kapur, Raj P.; Studholme, Colin; and Boldenow, Erica, "Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate" (2016). University Faculty Publications and Creative Works. 193.
https://digitalcommons.calvin.edu/calvin_facultypubs/193