Document Type
Article
Abstract
Vascular Cognitive Impairment and Dementia (VCID) affects 25-30% of stroke patients and includes cognitive impairments caused by vascular injury, such as post-stroke dementia. Rehabilitation has the potential to improve the quality of life for patients at risk of developing dementia. However, there is currently no reliable method to identify those at risk of dementia after a stroke. Several biomarkers, including ADRD (Alzheimer’s disease and related dementias) biomarkers (Ab, tau, NfL, and GFAP) and angiogenic factors (VEGF, Flt-1, Tie-2, PIGF, and FGF) have been associated with the development of dementia. Populations in Appalachia experience a higher incidence of stroke and related mortality compared to other groups. Given the elevated stroke rates in Appalachian communities, this study aims to investigate potential proteomic differences between patients from Appalachian and non-Appalachian counties. The primary goal of the study is to characterize the expression of post-stroke cognitive dementia biomarkers and to explore differences in the proteomic profiles of Appalachian and non-Appalachian populations.
Publication Date
11-11-2025
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Anil N, McLouth CJ, Hazelwood HS, Dahlke E, Frank JA, Millson N, Al-Kawaz M, Harp JP, Cranford W, Pahwa S, Dornbos D III, Fraser JF and Pennypacker KR (2025) Expression of dementia biomarkers in Appalachian and non-Appalachian ELVO patients during thrombectomy. Front. Neurosci. 19:1672803. doi: 10.3389/fnins.2025.1672803