Document Type
Article
Publication Title
Biochimica et Biophysica Acta - Molecular Cell Research
Abstract
Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. © 2009 Elsevier B.V. All rights reserved.
First Page
226
Last Page
233
DOI
10.1016/j.bbamcr.2009.11.006
Publication Date
2-1-2010
Recommended Citation
DeWard, Aaron D.; Eisenmann, Kathryn M.; Matheson, Stephen F.; and Alberts, Arthur S., "The role of formins in human disease" (2010). University Faculty Publications and Creative Works. 293.
https://digitalcommons.calvin.edu/calvin_facultypubs/293