Document Type

Article

Publication Title

Biochimica et Biophysica Acta - Molecular Cell Research

Abstract

Formins are a conserved family of proteins that play key roles in cytoskeletal remodeling. They nucleate and processively elongate non-branched actin filaments and also modulate microtubule dynamics. Despite their significant contributions to cell biology and development, few studies have directly implicated formins in disease pathogenesis. This review highlights the roles of formins in cell division, migration, immunity, and microvesicle formation in the context of human disease. In addition, we discuss the importance of controlling formin activity and protein expression to maintain cell homeostasis. © 2009 Elsevier B.V. All rights reserved.

First Page

226

Last Page

233

DOI

10.1016/j.bbamcr.2009.11.006

Publication Date

2-1-2010

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