Document Type
Article
Publication Title
Journal of Child Neurology
Abstract
This study utilized diffusion tensor imaging fiber tractography to examine the miscrostructural integrity of limbic and paralimbic white matter tracts in 36 children (age M = 124 months) with histories of early deprivation, raised from birth in orphanages and subsequently adopted into the United States, compared to 16 age-matched typically developing children. We found increased mean diffusivity bilaterally in the arcuate fasciculus and increased mean diffusivity and reduced fractional anisotropy bilaterally in the uncinate fasciculus and cingulum in children with early deprivation. Microstructural integrity of the left arcuate fasciculus and right cingulum was related to language and behavioral functioning, respectively. White matter abnormalities were also associated with length of deprivation and time in the adoptive home. Our findings suggest that white matter pathways, connecting limbic and paralimbic brain regions is abnormal in children with histories of early deprivation, with some pathways appearing more susceptible to early deprivation than others.
First Page
318
Last Page
325
DOI
10.1177/0883073812474098
Publication Date
3-1-2014
Recommended Citation
Kumar, Ajay; Behen, Michael E.; Singsoonsud, Piti; and Veenstra, Amy L., "Microstructural abnormalities in language and limbic pathways in orphanage-reared children: A diffusion tensor imaging study" (2014). University Faculty Publications and Creative Works. 410.
https://digitalcommons.calvin.edu/calvin_facultypubs/410