Document Type
Article
Publication Title
Journal of Biological Chemistry
Abstract
Alterations in Wnt/β-catenin signaling have been linked to abnormal kidney development and tumorigenesis. To gain more insights into the effects of these alterations, we created mice carrying a conditional deletion of the Apc tumor suppressor gene specifically in the renal epithelium. As expected, the loss of Apc leads to increased levels of β-catenin protein in renal epithelium. Most of these mice die shortly after birth, and multiple kidney cysts were found upon histological examination. Only rarely did these animals survive to adulthood. Analysis of these adults revealed severely cystic kidneys associated with the presence of renal adenomas. Our results confirm an important role for proper regulation of Wnt/β-catenin signaling in renal development and provide evidence that dysregulation of the pathway can initiate tumorigenesis in the kidney.
First Page
3938
Last Page
3945
DOI
10.1074/jbc.M410697200
Publication Date
2-4-2005
Recommended Citation
Qian, Chao Nan; Knol, Jared; Igarashi, Peter; and Lin, Fangming, "Cystic renal neoplasia following conditional inactivation of Apc in mouse renal tubular epithelium" (2005). University Faculty Publications and Creative Works. 526.
https://digitalcommons.calvin.edu/calvin_facultypubs/526