Document Type

Article

Publication Title

Angewandte Chemie

Abstract

An electron‐deficient tetranitroazacalixarene is shown to undergo reversible cyanide capture via nucleophilic aromatic substitution, yielding an unprecedented class of metastable dianionic macrocycle incorporating two Meisenheimer units, fully characterized by single‐crystal X‐ray diffraction, NMR, and electronic absorption spectroscopies. Acting as a chemical fuel, cyanide transiently drives the formation of this adduct, which can spontaneously regenerate the parent macrocycle under mild conditions, representing a rare demonstration of metastability in a Meisenheimer complex. The dynamic behavior of this system, reminiscent of out‐of‐equilibrium assemblies, is finely tunable through macrocycle concentration, counterion nature, solvent, and temperature. Detailed crystallographic, spectroscopic, and computational analyses reveal that intramolecular hydrogen bonding plays a key role in stabilizing the adduct. Comparative studies with simpler analogues further highlight the importance of macrocyclic preorganization and non‐covalent interactions in governing this reversible reactivity.

First Page

1

Last Page

10

DOI

https://doi.org/10.1002/ange.202511037

Publication Date

7-8-2025

Creative Commons License

Creative Commons Attribution-NonCommercial 4.0 International License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

Included in

Chemistry Commons

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