Start Date

2019

Description

  • Group B Streptococcus is a leading infectious cause of neonatal morbidity and mortality in the US1
  • Ascending infection in the mother can cause adverse birth outcomes2,3
  • GBS is defined as being beta-hemolytic, but about three percent of strains are non-hemolytic4
  • Recent data suggests that non-hemolytic strains can also pose health risks to infants5
  • Previously, we have seen that non-hemolytic strain GB37 displays hemolytic activity in liquid suspension
  • We hypothesize that non-hemolytic strains cause inflammation, oxidative stress, and invasion/adhesion in cells similarly to hemolytic strains

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Jan 1st, 12:00 AM

Non-hemolytic and hemolytic Group B Streptococcus: interactions with cells in vitro

  • Group B Streptococcus is a leading infectious cause of neonatal morbidity and mortality in the US1
  • Ascending infection in the mother can cause adverse birth outcomes2,3
  • GBS is defined as being beta-hemolytic, but about three percent of strains are non-hemolytic4
  • Recent data suggests that non-hemolytic strains can also pose health risks to infants5
  • Previously, we have seen that non-hemolytic strain GB37 displays hemolytic activity in liquid suspension
  • We hypothesize that non-hemolytic strains cause inflammation, oxidative stress, and invasion/adhesion in cells similarly to hemolytic strains