Start Date
2019
Description
- Group B Streptococcus is a leading infectious cause of neonatal morbidity and mortality in the US1
- Ascending infection in the mother can cause adverse birth outcomes2,3
- GBS is defined as being beta-hemolytic, but about three percent of strains are non-hemolytic4
- Recent data suggests that non-hemolytic strains can also pose health risks to infants5
- Previously, we have seen that non-hemolytic strain GB37 displays hemolytic activity in liquid suspension
- We hypothesize that non-hemolytic strains cause inflammation, oxidative stress, and invasion/adhesion in cells similarly to hemolytic strains
Recommended Citation
Harlow, Olivia S; Houskamp, Ethan; Anumolu, Natalie; Manning, Shannon; and Boldenow, Erica, "Non-hemolytic and hemolytic Group B Streptococcus: interactions with cells in vitro" (2019). Summer Research. 12.
https://digitalcommons.calvin.edu/summer_research/2019/Posters/12
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Cell and Developmental Biology Commons
Jan 1st, 12:00 AM
Non-hemolytic and hemolytic Group B Streptococcus: interactions with cells in vitro
- Group B Streptococcus is a leading infectious cause of neonatal morbidity and mortality in the US1
- Ascending infection in the mother can cause adverse birth outcomes2,3
- GBS is defined as being beta-hemolytic, but about three percent of strains are non-hemolytic4
- Recent data suggests that non-hemolytic strains can also pose health risks to infants5
- Previously, we have seen that non-hemolytic strain GB37 displays hemolytic activity in liquid suspension
- We hypothesize that non-hemolytic strains cause inflammation, oxidative stress, and invasion/adhesion in cells similarly to hemolytic strains