Start Date
2021
Description
- Parkinson’s disease (PD) is the most common neurodegenerative movement disorder
- Patients experience rigidity, tremor, and bradykinesia
- Due to a loss of dopaminergic neurons in the substantia nigra
- Accumulation of α-synuclein Lewy bodies
- Genetic risks include: LRRK2 and GBA1
- GBA1 is a mutation within gene coding for Gcase (Glucocerebrosidase) which is a lipid hydrolase within the lysosome, leading to a loss of function.
- LRRK2 is a hyperactivation mutation in the region coding for the enzyme Leucine Rich Repeat Kinase 23
Recommended Citation
Beezhold, Brenna, "Investigating the relationship between GCase and pathology in Parkinson’s disease" (2021). Summer Research. 8.
https://digitalcommons.calvin.edu/summer_research/2021/Posters/8
Included in
Jan 1st, 12:00 AM
Investigating the relationship between GCase and pathology in Parkinson’s disease
- Parkinson’s disease (PD) is the most common neurodegenerative movement disorder
- Patients experience rigidity, tremor, and bradykinesia
- Due to a loss of dopaminergic neurons in the substantia nigra
- Accumulation of α-synuclein Lewy bodies
- Genetic risks include: LRRK2 and GBA1
- GBA1 is a mutation within gene coding for Gcase (Glucocerebrosidase) which is a lipid hydrolase within the lysosome, leading to a loss of function.
- LRRK2 is a hyperactivation mutation in the region coding for the enzyme Leucine Rich Repeat Kinase 23