Start Date
2022
Description
ENL is a histone reader that is part of the super elongation complex and is primarily involved in chromatin and gene expression regulation. ENL has also been found to play an essential role in the progression of a spectrum of acute myeloid leukemia (AML). Some hotspot mutations of its reader module, the YEATS domain, have been found to be oncogenic. For this reason, we explored the efficacy of a newly developed ENL PROTAC degrader in its ability to degrade wild-type and mutant ENL protein and suppress oncogene expression in cancer cells.
Recommended Citation
Harsh, Josiah; Xue, Zhaoyu; Xuan, Fan; Shi, Xiaobing; and Wen, Hong, "Targeting Histone Reader ENL with PROTAC Degrader" (2022). Summer Research. 23.
https://digitalcommons.calvin.edu/summer_research/2022/Posters/23
Included in
Targeting Histone Reader ENL with PROTAC Degrader
ENL is a histone reader that is part of the super elongation complex and is primarily involved in chromatin and gene expression regulation. ENL has also been found to play an essential role in the progression of a spectrum of acute myeloid leukemia (AML). Some hotspot mutations of its reader module, the YEATS domain, have been found to be oncogenic. For this reason, we explored the efficacy of a newly developed ENL PROTAC degrader in its ability to degrade wild-type and mutant ENL protein and suppress oncogene expression in cancer cells.