Start Date
2022
Description
Bacterial resistance to antibiotics is a growing public health threat. Each year, more than 2.8 million antibioticresistant infections occur in the United States and 35,000 people die as a consequence. Fluoroquinolone (FQ) agents targeting the essential bacterial type II topoisomerases DNA gyrase and topoisomerase IV, exemplified by ciprofloxacin, have been in clinical use since the 1980’s and shown to be useful antibiotics. Unfortunately, heavy use of the FQs has inevitably led to the development of FQ-resistant pathogens
Recommended Citation
Stonehouse, Colton J. and Barbachyn, Michael, "An Approach to the Synthesis of 3-Quinazolinedione Carboxylic Acids: Putative Antibiotics" (2022). Summer Research. 46.
https://digitalcommons.calvin.edu/summer_research/2022/Posters/46
Included in
An Approach to the Synthesis of 3-Quinazolinedione Carboxylic Acids: Putative Antibiotics
Bacterial resistance to antibiotics is a growing public health threat. Each year, more than 2.8 million antibioticresistant infections occur in the United States and 35,000 people die as a consequence. Fluoroquinolone (FQ) agents targeting the essential bacterial type II topoisomerases DNA gyrase and topoisomerase IV, exemplified by ciprofloxacin, have been in clinical use since the 1980’s and shown to be useful antibiotics. Unfortunately, heavy use of the FQs has inevitably led to the development of FQ-resistant pathogens