Start Date
2019
Description
- Antibiotic resistance comes from bacterial mutations in the antibiotic binding site (which prevents antibiotic binding)
- These new antibiotics target both DNA Gyrase and DNA Topoisomerase IV (fluoroquinolones)
- This improves efficacy because if one binding site is mutated, the other is still available
- This makes it harder for bacteria to form resistance against the drug
Recommended Citation
Knapp, Sara; Baker, Rachael; and Wilstermann, Amy, "Determining the Effectiveness of Drugs using EC50 and MIC Assays" (2019). Summer Research. 18.
https://digitalcommons.calvin.edu/summer_research/2019/Posters/18
COinS
Jan 1st, 12:00 AM
Determining the Effectiveness of Drugs using EC50 and MIC Assays
- Antibiotic resistance comes from bacterial mutations in the antibiotic binding site (which prevents antibiotic binding)
- These new antibiotics target both DNA Gyrase and DNA Topoisomerase IV (fluoroquinolones)
- This improves efficacy because if one binding site is mutated, the other is still available
- This makes it harder for bacteria to form resistance against the drug