Start Date

2019

Description

The phenyloxazolidinones, exemplified by linezolid (1, marketed as Zyvox™), have emerged as useful antibacterial agents for treating a variety of infections caused by problematic Gram-positive bacteria. 1 Another clinical phenyloxazolidinone with somewhat improved potency and safety properties is PNU-288034 (2). 2 PNU288034 incorporates a 1,1-dioxothiomorpholine ring system and an additional fluorine atom.

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Jan 1st, 12:00 AM

Progress Toward the Synthesis of an Oxazolidinone Antibacterial Agent Incorporating a Bicyclo[1.1.1]pentane (BCP) Ring System

The phenyloxazolidinones, exemplified by linezolid (1, marketed as Zyvox™), have emerged as useful antibacterial agents for treating a variety of infections caused by problematic Gram-positive bacteria. 1 Another clinical phenyloxazolidinone with somewhat improved potency and safety properties is PNU-288034 (2). 2 PNU288034 incorporates a 1,1-dioxothiomorpholine ring system and an additional fluorine atom.