Start Date
2019
Description
The phenyloxazolidinones, exemplified by linezolid (1, marketed as Zyvox™), have emerged as useful antibacterial agents for treating a variety of infections caused by problematic Gram-positive bacteria. 1 Another clinical phenyloxazolidinone with somewhat improved potency and safety properties is PNU-288034 (2). 2 PNU288034 incorporates a 1,1-dioxothiomorpholine ring system and an additional fluorine atom.
Recommended Citation
Medendorp, Evamarie and Barbachyn, Michael, "Progress Toward the Synthesis of an Oxazolidinone Antibacterial Agent Incorporating a Bicyclo[1.1.1]pentane (BCP) Ring System" (2019). Summer Research. 5.
https://digitalcommons.calvin.edu/summer_research/2019/Posters/5
Progress Toward the Synthesis of an Oxazolidinone Antibacterial Agent Incorporating a Bicyclo[1.1.1]pentane (BCP) Ring System
The phenyloxazolidinones, exemplified by linezolid (1, marketed as Zyvox™), have emerged as useful antibacterial agents for treating a variety of infections caused by problematic Gram-positive bacteria. 1 Another clinical phenyloxazolidinone with somewhat improved potency and safety properties is PNU-288034 (2). 2 PNU288034 incorporates a 1,1-dioxothiomorpholine ring system and an additional fluorine atom.