Preparation of a Novel Trifluoroborate Reagent and Initial Investigations into its Use in Suzuki-Miyaura Cross-Coupling Reactions.

Presenter Information

KangJin Lee
Michael Barbachyn, Calvin UniversityFollow

Start Date

2019

Comments

Bacterial resistance to antibiotics is a growing public health threat. Each year, ~2 million infections and 23,000 deaths are caused by antibiotic resistance in the US. 1 Relatively recently, a gyrase inhibitor lead compound called QPT-1 has been shown to be active against multidrug-resistant bacteria, including ciprofloxacin-resistant strains of Staphylococcus aureus. 2 This is apparently because QPT-1 engages in unique binding interactions with the GyrB subunit of gyrase, in contrast with fluoroquinolones such as ciprofloxacin, which only bind to GyrA

Recommended Citation

Lee, KangJin and Barbachyn, Michael, "Preparation of a Novel Trifluoroborate Reagent and Initial Investigations into its Use in Suzuki-Miyaura Cross-Coupling Reactions." (2019). Summer Research. 6.
https://digitalcommons.calvin.edu/summer_research/2019/Posters/6