Start Date
2021
Description
- Trichloroethylene (TCE) is an industrial solvent commonly used as a metal degreaser which accumulates as a toxicant in water and soil1
- There is little known about how environmental toxicants and infectious diseases (such as Group B Streptococcus) interact in pregnant women2
- Cytokines IL-1β, IL-6, IL-8 and TNF-α are proinflammatory cytokines important to immune function2
- Previous studies have shown that DCVC, a metabolite of TCE, has immunosuppressive effects3
- This summer we sought to discover a more comprehensive picture of DCVC’s effects on immunosuppression in macrophage-like cells
Recommended Citation
Schellenboom, Emily; Scheeres, Eleanor; Houskamp, Ethan; Caruso, Rita Loch −; Harris, Sean; and Boldenow, Erica, "Environmental Toxicant Trichloroethylene (TCE) Impacts Macrophage Function" (2021). Summer Research. 14.
https://digitalcommons.calvin.edu/summer_research/2021/Posters/14
Included in
Jan 1st, 12:00 AM
Environmental Toxicant Trichloroethylene (TCE) Impacts Macrophage Function
- Trichloroethylene (TCE) is an industrial solvent commonly used as a metal degreaser which accumulates as a toxicant in water and soil1
- There is little known about how environmental toxicants and infectious diseases (such as Group B Streptococcus) interact in pregnant women2
- Cytokines IL-1β, IL-6, IL-8 and TNF-α are proinflammatory cytokines important to immune function2
- Previous studies have shown that DCVC, a metabolite of TCE, has immunosuppressive effects3
- This summer we sought to discover a more comprehensive picture of DCVC’s effects on immunosuppression in macrophage-like cells