Start Date
2022
Description
Impaired membrane repair leads to muscular dystrophies like Miyoshi Myopathy and LGMD2B1. The mechanism behind membrane repair is not well understood, and there are few studies on membrane repair in cardiomyocytes. Research in nonmuscle cells suggest that lysosomes are a source of membranes for repairing injuries2. Few lysosomes were found in cardiomyocytes compared to non cardiomyocytes. Therefore, we investigated the ER and Golgi as potential organelles involved in membrane repair in cardiomyocytes. We used Sec22b to investigate ER to Golgi in membrane repair in cardiomyocytes because it is an ER-Golgi protein involved in membrane fusion and Golgi vesicle trafficking in non-muscle cells3. We hypothesized that if the ER and Golgi are involved in membrane repair, we may observe greater Sec22b trafficking to the Golgi.
Recommended Citation
Tsurho, Visakuo; Chen, Hsin-Yu; and Michele, Daniel, "ER-Golgi in membrane repair in cardiomyocytes" (2022). Summer Research. 45.
https://digitalcommons.calvin.edu/summer_research/2022/Posters/45
Included in
ER-Golgi in membrane repair in cardiomyocytes
Impaired membrane repair leads to muscular dystrophies like Miyoshi Myopathy and LGMD2B1. The mechanism behind membrane repair is not well understood, and there are few studies on membrane repair in cardiomyocytes. Research in nonmuscle cells suggest that lysosomes are a source of membranes for repairing injuries2. Few lysosomes were found in cardiomyocytes compared to non cardiomyocytes. Therefore, we investigated the ER and Golgi as potential organelles involved in membrane repair in cardiomyocytes. We used Sec22b to investigate ER to Golgi in membrane repair in cardiomyocytes because it is an ER-Golgi protein involved in membrane fusion and Golgi vesicle trafficking in non-muscle cells3. We hypothesized that if the ER and Golgi are involved in membrane repair, we may observe greater Sec22b trafficking to the Golgi.